产品名称 CD59a, Mouse Antibody from HYCULT BIOTECH
产品货号 HM1116F
产品价格 现货询价,电话:010-67529703
产品规格 100 µg
产品品牌 HYCULT BIOTECH
产品概述
产品详情
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Antigenic SpecificityCD59a, Mouse
Clone7A6
Host SpeciesMouse
Reactive Speciesmouse
IsotypeIgG1
Formatfluorescein (FITC) conjugate
Size100 µg
Concentration100 µg/ml
Applicationsfrozen sections, FC, functional studies, immunoassay, IF, WB
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DescriptionThe monoclonal antibody 7A6 (previously known as mCD59.3) recognizes mouse CD59a, a potent inhibitor of the complement membrane attack complex (MAC) action. CD59 regulates the formation and function of the lytic C5b-9 complex by binding C8 and preventing the unfolding and membrane insertion of C9 and by binding C9 and restricting its polymerization.CD59 is a small (18 - 25 kDa) molecule, linked to the cell membrane through a glycosyl phosphatidylinositol (GPI) anchor and comprising 77 amino acids with a single N-linked carbohydrate group at Asn-18. Analogues of CD59 can be found in all species with similar structures and sizes. In contrast to all other species, mice have two genes encoding a CD59a and a CD59b protein. These two molecules are 63% identical at the amino acid level and share all major structural features. CD59a is broadly distributed on endothelia, erythrocytes, platelets and on numerous other cell types in organs, a distribution pattern resembling that of CD59 in other species. Expression of CD59b is restricted to germ cell elements in the testis and mature spermatozoa. Both CD59a and CD59b inhibit human and rodent complement with similar efficiency. CD59 may be involved in rheumatoid arthritis, motor nerve injury in the Guillain-Barre sydrome and in other diseases where defective inhibition of complement activation on self tissue is involved. Furthermore, CD59 may play an important part in abrogating the effects of complement attack in renal disease. Its presence and protective effect have already been demonstrated on human renal cells.
ImmunogenmCD59a-Fc
Other NamesMembrane attack complex inhibition factor, MACIF, MAC-inhibitory protein, Protectin, CD59.
Gene, Accession #CD59A
Catalog #HM1116F
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Order / More InfoCD59a, Mouse Antibody from HYCULT BIOTECH
Product Specific Referencesn/a
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