产品名称 MASP-2, Human Antibody from HYCULT BIOTECH
产品货号 HM2190
产品价格 现货询价,电话:010-67529703
产品规格 100 µg
产品品牌 HYCULT BIOTECH
产品概述
产品详情
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Antigenic SpecificityMASP-2, Human
Clone8B5
Host SpeciesRat
Reactive Specieshuman
IsotypeIgG1
Formatunconjugated
Size100 µg
Concentration100 µg/ml
Applicationsimmunoassay, WB
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DescriptionThe monoclonal antibody 8B5 reacts with the CCP1/2-SP fragment of human MASP-2. MASP-2 is a trypsin-like serine protease and plays an important rol in the initiation of the MBL complement activation pathway. Three pathways of complement activation have been reported: the antibody-dependent classical pathway, the antibody-independent alternative pathway and the lectin pathway. Activation of each pathway involves formation of serine protease complexes, which results in activation of the central complement component C3. In the lectin pathway, mannose binding-lectin (MBL)-associated serine proteases (MASPs) form complexes with polymeric lectin molecules which are involved in pattern recognition. Upon binding of the recognition molecules to carbohydrates on the surface of micro organisms, MASPs are converted to their active forms and initiate complement activation. Three types of human MASP have been reported. MASP-1, MASP-2 and MASP-3. Mannan-binding lectin (MBL) and ficolins, in complex with MBL-associated serin proteases (MASPs), are capable of activation the complement system, thus mediating the destruction of infectious agents. MASP-2 cleaves C4 and C2 and is crucial for the activation of downstream complement components.
Immunogenn/a
Other Namesn/a
Gene, Accession #n/a
Catalog #HM2190
Price
Order / More InfoMASP-2, Human Antibody from HYCULT BIOTECH
Product Specific Referencesn/a
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