产品名称 TNF-RII, Mouse Antibody from HYCULT BIOTECH
产品货号 HM1011
产品价格 现货询价,电话:010-67529703
产品规格 100 µg
产品品牌 HYCULT BIOTECH
产品概述
产品详情
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Antigenic SpecificityTNF-RII, Mouse
CloneHM12
Host SpeciesRat
Reactive Speciesmouse
IsotypeIgG2a
Formatunconjugated
Size100 µg
Concentration100 µg/ml
Applicationsfrozen sections, FC, functional studies, immunoassay, IP, WB
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DescriptionThe monoclonal antibody HM102 recognizes the extracellular part of membrane-bound TNF-RII as well as the soluble form of TNF-RII which is generated by proteolytic cleavage of the extracellular domain. The soluble form can still bind TNF-alpha with high affinity and functions as a TNF-alpha antagonist. TNF-alpha is an important signalling protein in the immune system which can activate inflammatory responses, induce apoptosis, regulate cellular proliferation, and may even promote cancer progression. TNF-alpha can bind to two structurally distinct membrane receptors, TNF-RI and TNFRII, which have both distinct and overlapping downstream signaling cascades. TNFRI is believed to be expressed on nearly all cell types, whereas TNFRII exhibits more restricted expression, being found on certain subpopulations of immune cells and several other cell types. A dominant role of TNFRII has been shown in thymocyte activation by TNF-alpha, whereas induction of cytotoxicity and other functions are mediated largely by TNF-RI. TNF-RI is equally well activated by both the 17 kDa soluble and 26 kDa membrane-bound form, whereas TNF-RII is activated only by the membrane bound form of TNF-alpha. The antibody is a agonistic receptor modulating antibody. It enhances in vitro TNF alpha responses by increasing the affinity of the soluble form of TNF-alpha for TNF-RII.
Immunogenn/a
Other NamesTumor necrosis factor receptor superfamily member 1B, CD120b, TNF-R2, p75, p80 TNF-alpha receptor.
Gene, Accession #Tnfrsf1b
Catalog #HM1011
Price
Order / More InfoTNF-RII, Mouse Antibody from HYCULT BIOTECH
Product Specific Referencesn/a
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