产品名称 Collagen II, Mouse Antibody from HYCULT BIOTECH
产品货号 HM1062-FS
产品价格 现货询价,电话:010-67529703
产品规格 0.5 mg
产品品牌 HYCULT BIOTECH
产品概述
产品详情
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Antigenic SpecificityCollagen II, Mouse
CloneCIIC1
Host SpeciesMouse
Reactive Speciesmouse, bovine, chicken, human, rat
IsotypeIgG2a
Formatunconjugated
Size0.5 mg
Concentration100 µg/ml
Applicationsfrozen sections, functional studies, immunoassay, paraffin sections
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DescriptionThe monoclonal antibody CIICI reacts with the C1 epitope (triple helical position 358-364) of collagen type II. Collagen is a structural protein in bone, cartillage and connective tissue. Collagen type II (CII) is the major collagen of the nucleus pulposa (a component of spine), cartilage and vitreous (a component of the eye). The most commonly used animal model for rheumatoid arthritis (RA) is the collagen-induced arthritis (CIA). Transfer of collagen type II specific monoclonal antibodies induces an acute form of arthritis (collagen type II antibody induced arthritis, CAIA). The monocolonal antibody CIIC1 has been shown to induce CAIA in naive mice after injection of lipopolysacharide (LPS). However, in combination with the monoclonal antibody M2139, binding to the J1 epitope of CII, the pair of monoclonal antibodies induce arthritis in different strains of mice without any other stimulants. The presence of secondary stimulus, LPS, increases the disease incidence and severity. The monoclonal antibody CIIC1 is cross reactive with rat, bovine, chicken and human CII.
Immunogenn/a
Other Namesn/a
Gene, Accession #n/a
Catalog #HM1062-FS
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Order / More InfoCollagen II, Mouse Antibody from HYCULT BIOTECH
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