| 产品详情 |
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| Product Name | A-674563 |
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| Description | Highly Purified (~95%). Three related forms of the kinase Akt (1, 2, 3, also known as protein kinase B isoforms PKBalpha, beta, gamma) modulate cell proliferation, metabolism, and survival, as well as angiogenesis. A-674563 is an orally available, ATP-competitive, and reversible inhibitor of Akt (Ki =11nM for Akt1). It shows inhibitory activity against PKA and Cdk2 with IC50 values of 16 and 46 nM, respectively, but is 10- to >1,800-fold selective for Akt1 versus additional kinases in the CMGC, CAMK, and TK families. A-674563 reduces phosphorylation of Akt downstream targets in cells and slows proliferation of tumor cells in vitro with an EC50 value of 0.4uM.1 In vivo, 40mg/kg/day A-674563 in combination with 15mg/kg/day paclitaxel was shown to decrease tumor growth in a PC-3 prostate cancer mouse xenograft model. CAS Number: 552325-73-2 Molecular Formula: C22H22N4O Solubility: ~0.5mg/ml in a 1:1 solution of DMF:PBS (pH 7.2); ~10mg/ml in EtOH; ~15mg/ml in DMSO; ~20mg/ml in DMF Molecular Weight: 358.4 Lambda m |
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| Size | 500ug, 1mg, 5mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | (αS-[[[5-(3-methyl-1H-indazol-5-yl)-3-pyridinyl]oxy]methyl]- benzeneethanamine) |
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| Gene, Accession, CAS # | CAS: 552325-73-2 |
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| Catalog # | 349624 |
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| Order / More Info | A-674563 from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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