| 产品详情 |
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| Product Name | A740003 |
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| Description | Purity ~98% (HPLC). A highly potent, selective, competitive antagonist of P2X7 purinegic receptor (IC50 = 18nM and 40nM, respectively as measured by Bz-ATP-stimulated Ca2+ flux). Does not affect other P2 receptors even at 10uM concentrations. Blocks agonist-evoked IL-1b release (IC50 = 156nM) and pore formation (IC50 = 92nM) in differentiated human THP-1 cells. Also shown to reduce carrageenan and Freund's adjuvant -induced thermal hyperalgesia (ED50 = 38-54mg/kg, i.p) and neuropathic pain induced by chronic constriction injury (CIC) of the sciatic nerve. Primary Target: P2X7 Primary Target IC50: 18nM Solubility: Warm DMSO |
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| Size | 5mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | A740003 (N-(1-{[(cyanoimino)(5-quinolinylamino) methyl] amino}-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide, A 740003, P2X7 Purinegic Receptor, A740003, A740003) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217137 |
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| Price | |
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| Order / More Info | A740003 from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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