| 产品详情 |
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| Antigenic Specificity | IKK beta |
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| Clone | monoclonal |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG1 |
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| Format | purified |
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| Size | 80 µl, 400 µl |
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| Concentration | n/a |
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| Applications | WB. RUO |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA (MIM 164014), or RELB (MIM 604758) to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008, or NFKBIB, MIM 604495), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664, or IKBKB) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine). This IKK beta antibody was raised using purified His-tagged recombinant full length human IKK beta. |
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| Immunogen | Human IKK beta. |
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| Other Names | I-kappa-B kinase 2; I-kappa-B-kinase beta; IKK-B; IKK-beta; IKK2; IKKB; IkBKB; NFKBIKB; Nuclear factor NF-kappa-B inhibitor kinase beta; kinase IKK-beta; Inhibitor of nuclear factor kappa-B kinase subunit beta; IKK beta |
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| Gene, Accession # | Accession: NP_001177649.1, NP_001229707.1, NP_001547.1, SwissProt: O14920 |
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| Catalog # | abx025555 |
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| Price | |
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| Order / More Info | IKK beta Antibody from ABBEXA |
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| Product Specific References | n/a |
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