| 产品详情 |
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| Product Name | AAL-993 |
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| Description | Purity >98% by TLC. AAL-993 is a potent, selective and cell-permeable inhibitor of VEGFR-1 (IC50 = 130 nM), VEGFR-2 (IC50 = 23 nM) and VEGFR-3 (IC50 = 18nM). At higher concentrations it inhibits PDGFR (640 nM), c-Kit (236 nM) and CSF-1R (380 nM). Inactive at other kinases such as EGFR, FGFR-1, CDK-1, Tie-2, c-Met, IGF-1R, c-Src and c-Abl. X-ray crystal studies on AAL-993 complexed to the catalytic domain of diphosphorylated VEGFR- 2 indicates that it binds to an inactive conformation of the protein. AAL-993 inhibits VEGF-induced angiogenesis (mouse model). |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 2-((4-Pyridyl)methyl)amino-N-(3-(trifluoromethyl)phenyl)benzamide |
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| Gene, Accession, CAS # | CAS: 269390-77-4 |
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| Catalog # | LS-H3287 |
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| Price | |
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| Order / More Info | AAL-993 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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