| 产品详情 |
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| Product Name | A-674563 |
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| Description | Purity >95%. Three related forms of the kinase Akt (1, 2, 3, also known as protein kinase B isoforms PKBAlpha, Beta, Gamma) modulate cell proliferation, metabolism, and survival, as well as angiogenesis. A-674563 is an orally available, ATP-competitive, and reversible inhibitor of Akt (Ki = 11 nM for Akt1). It shows inhibitory activity against PKA and Cdk2 with IC50 values of 16 and 46 nM, respectively, but is 10- to >1,800-fold selective for Akt1 versus additional kinases in the CMGC, CAMK, and TK families. A-674563 reduces phosphorylation of Akt downstream targets in cells and slows proliferation of tumor cells in vitro with an EC50 value of 0.4 µM. In vivo, 40 mg/kg/day A-674563 in combination with 15 mg/kg/day paclitaxel was shown to decrease tumor growth in a PC-3 prostate cancer mouse xenograft model. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | aS-[[[5-(3-methyl-1H-indazol-5-yl)-3-pyridinyl]oxy]methyl]-benzeneethanamine |
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| Gene, Accession, CAS # | CAS: 552325-73-2 |
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| Catalog # | LS-H6358 |
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| Order / More Info | A-674563 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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