| 产品详情 |
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| Antigenic Specificity | CIC |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, mouse, rat |
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| Isotype | n/a |
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| Format | unconjugated |
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| Size | 100ug |
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| Concentration | 0.5-1mg/ml, actual concentration varies by lot. |
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| Applications | ELISA, IHC |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Rabbit IgG polyclonal Picoband™ antibody for CIC detection. Tested with IHC-P, Direct ELISA in Human;Mouse;Rat. No cross reactivity with other proteins. Protein capicua homolog is a protein that in humans is encoded by the CIC gene. The protein encoded by this gene is an ortholog of the Drosophila melanogaster capicua gene, and is a member of the high mobility group (HMG)-box superfamily of transcriptional repressors. This protein contains a conserved HMG domain that is involved in DNA binding and nuclear localization, and a conserved C-terminus. Studies suggest that the N-terminal region of this protein interacts with Atxn1 (GeneID:6310), to form a transcription repressor complex, and in vitro studies suggest that polyglutamine-expansion of ATXN1 may alter the repressor activity of this complex. Mutations in this gene have been associated with olidogdendrogliomas (PMID:21817013). In addition, translocation events resulting in gene fusions of this gene with both DUX4 (GeneID:100288687) and FOXO4 (GeneID:4303) have been associated with round cell sarcomas. This gene is mapped to 19q13.2. Alternative splicing results in multiple transcript variants encoding different isoforms. |
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| Immunogen | E. coli-derived human CIC recombinant protein (Position: E1433-Q1527). |
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| Other Names | Protein capicua homolog; CIC; KIAA0306 |
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| Gene, Accession # | CIC, UniProt: Q96RK0 |
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| Catalog # | A00385-1 |
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| Price | |
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| Order / More Info | CIC Antibody from BOSTER BIO |
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| Product Specific References | n/a |
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