产品名称 C3a, Mouse Antibody from HYCULT BIOTECH
产品货号 HM1072
产品价格 现货询价,电话:010-67529703
产品规格 100 µg
产品品牌 HYCULT BIOTECH
产品概述
产品详情
Edit&nbsp
Antigenic SpecificityC3a, Mouse
Clone3/11
Host SpeciesRat
Reactive Speciesmouse
IsotypeIgG2a
Formatunconjugated
Size100 µg
Concentration100 µg/ml
ApplicationsFC, functional studies, immunoassay, WB
Reviews / RatingsIf you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
DescriptionThe monoclonal antibody 3/11 recognizes C3a, an activated fragment of the complement protein C3, a 190 kDa protein which is the most abundant complement protein in serum. C3 is the third component of the complement system and plays a central role in the complement cascade. The three pathways of compliment activation come together- at this key molecule. Cleavage of the pivotal complement component C3 results in the generation of a set of effector molecules which have diverse biological functions. The cleavage product C3b promotes complement acrtivation and the subsequent formation of the membrane attack complex. C3a, the small (ca. 10 kDa) cleavage product possesses anaphylatoxic as well as immunoregulatory- properties. It exerts its function through a specific receptor (C3aR), which belongs to the G-protein coupled receptor family. Expression of C3aR- has been reported in many cell types including myeloid and non-myeloid cells. Expression of C3aR on haematopoietic stem/progenitor cells has been shown to promote the trafficking/homing of these cells to the BM. Engagement of C3aR on DCs and T cells has been shown to up-regulate these cell functions. The monoclonal antibody 3/11 reacts specifically with the C3a anaphylatoxin, providing a tool for monitoring acute complement activation (C3a generation) in experimental mouse models.
ImmunogenPurified mouse C3
Other Namesn/a
Gene, Accession #n/a
Catalog #HM1072
Price
Order / More InfoC3a, Mouse Antibody from HYCULT BIOTECH
Product Specific Referencesn/a
产品资料