产品名称 Calprotectin, Human Antibody from HYCULT BIOTECH
产品货号 HM2156BT
产品价格 现货询价,电话:010-67529703
产品规格 50 µg
产品品牌 HYCULT BIOTECH
产品概述
产品详情
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Antigenic SpecificityCalprotectin, Human
Clone270
Host SpeciesMouse
Reactive Specieshuman, rhesus monkey
IsotypeIgG1
Formatbiotin conjugate
Size50 µg
Concentration100 µg/ml
Applicationsfrozen sections, FC, immunoassay, IF, IP, paraffin sections, WB
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DescriptionDoes not react with: mouse. The monoclonal antibody 27E10 recognizes an epitope specific for the S100A8/A9 heterocomplex that is not exposed on the individual subunits S100A8 (MRP8, calgranulin-A) or S100A9 (MRP14, calgranulin-B). The calcium-binding migration inhibitory factor-related proteins, MRP-8 (S100A8) and MRP-14 (S100A9) belong to the S100 protein family. The expression of these proteins is largely confined to the cytosol of neutrophils and monocytes. The complex formation of these proteins is a calcium-dependent process. The S100A8/A9 heterocomplex, also called MRP-8/MRP-14 complex or calprotectin, comprises 60% of the cytoplasmic protein fraction of circulating polymorphonuclear granulocytes and is also found in monocytes, macrophages and ileal tissue eosinophils. Peripheral blood monocytes carry the antigen extra- and intracellularly, neutrophils only intracellularly. The S100A8/A9 complex has antibacterial, antifungal, immunomodulating and antiproliferative effects. Besides this it is a potent chemotactic factor for neutrophils. Plasma concentrations are elevated in diseases associated with increased neutrophil activity, like inflammatory bowel disease. Granulocytes terminate their existence after transmigration through the intestinal wall. Therefore calprotectin is also detectable in feces. Elevated levels of calprotectin have been observed in body fluids such as plasma, saliva, gingival crevicular fluid, stools, and synovial fluid during infection and inflammatory conditions. The monoclonal antibody 27E10 can be used for early detection of inflammatory macrophages, for the characterization of tumorous tissues and the monitoring of peripheral blood cell cultures. The antibody 27E10 does not react with lymphocytes or platelets.
ImmunogenHuman blood monocytes
Other NamesS100A8/A9, MRP-8/MRP-14, calprotectin, calgranulin-A/calgranulin-B, L1-protein
Gene, Accession #n/a
Catalog #HM2156BT
Price
Order / More InfoCalprotectin, Human Antibody from HYCULT BIOTECH
Product Specific Referencesn/a
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