| 产品详情 |
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| Product Name | 2-PCPA (hydrochloride) |
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| Description | Purity >98%. Histones contain unstructured N-terminal residues that are the site of numerous post-translational modifications, involving acetylation, methylation, ubiquitination, and sumoylation to produce a specific gene regulatory outcome. Complementary enzymes catalyze the addition and removal of these modifications as needed. The amine oxidase domain-containing enzyme lysine-specific demethylase 1 (LSD1) is a member of one of two classes of histone demethylases capable of demethylating lysine residues. LSD1 shares similar catalytic sites with monoamine oxidases (MAO) A and B, the inhibition of which are used clinically to treat depression, anxiety, and Parkinson's disease. 2-PCPA is an irreversible, mechanism-based inhibitor of LSD1 with an IC50 value of 20.7 µM and a Ki value of 242.7 µM that effectively inhibits histone demethylation in vivo . Although not as selective, 2-PCPA also irreversibly inhibits monoamine oxidase (MAO) A and MAO B with IC50 values of 2.3 and 0.95 µM and Ki values of 101.9 and 16 µM, respectively. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | (1R,2S)-rel -2-phenyl-cyclopropanamine, monohydrochloride, trans-2-Phenylcyclopropylamine, Tranylcypromine |
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| Gene, Accession, CAS # | CAS: 1986-47-6 |
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| Catalog # | LS-H6014 |
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| Order / More Info | 2-PCPA (hydrochloride) from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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