| 产品详情 |
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| Product Name | 4μ8C |
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| Description | Purity >97% by NMR and TLC. 4u8C is a selective inhibitor of IRE1a ribonuclease (RNase) activity (IC50 = 60 nM). Covalently binds to lysine 907 in the IRE1 endonuclease domain, blocking substrate access to the active site of IRE1a and inactivating both XBP1 splicing and IRE1a-mediated mRNA degradation but not IRE1 kinase activity. Inhibits IRE1a in response to hypoxia or other ER stress-inducing agents but has no effect on proliferation or clonogenic survival of hypoxic cells. Blocks production of IL-4, IL-5 and IL-13 production in T cells. 4u8C prevents the splicing of the XBP1 mRNA in response to ER stress caused by mutant proinsulin production in pancreatic b-cells. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 7-Hydroxy-4-methyl-2-oxo-2H-1-benzopyran-8-carboxaldehyde |
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| Gene, Accession, CAS # | CAS: 14003-96-4 |
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| Catalog # | LS-H14567 |
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| Price | |
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| Order / More Info | 4μ8C from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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