| 产品详情 |
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| Product Name | G-749 |
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| Description | An FLT3 kinase inhibitor (IC50s = 2.1-38.1 nM for wild-type and constitutively active mutant FLT3s); inhibits growth of human leukemia cell lines that express FLT3-ITD mutant kinase (IC50s = 3.5 and 7.5 nM for MV4-11 and Molm-14 cells, respectively); reduces tumor growth and increases survival in a dose-dependent manner in MV4-11 and Molm-14 murine leukemia xenograft models; reduces growth of bone marrow blasts derived from acute myeloid leukemia patients |
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| Size | 10 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | G749 FLT-3 FLT3ITD MV411 Molm14 BaF3 AML bearing internal-tandem duplication |
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| Gene, Accession, CAS # | CAS: 1457983-28-6 |
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| Catalog # | 22139-10 |
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| Order / More Info | G-749 from CAYMAN CHEMICAL COMPANY |
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| Product Specific References | n/a |
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