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| Product Name | NDP, 25-133aa, Human, His tag, E.coli (Denatured) |
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| Description | Purity: > 80% by SDS - PAGE Format: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% glycerol. Norrin precursor, also known as NDP, is a secreted regulatory protein. It activates the canonical Wnt signaling pathway through FZD4 and LRP5 coreceptor. This protein plays a central role in retinal vascularization by acting as a ligand for FZD4 that signals via stabilizing beta-catenin (CTNNB1) and activating LEF/TCF-mediated transcriptional programs. It may be involved in a pathway that regulates neural cell differentiation and proliferation. Recombinant human NDP protein, fused to His-tag at N-terminus, was expressed in E.coli. |
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| Size | 250ug, 50ug, 10ug |
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| Concentration | n/a |
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| Applications | SDS-PAGE |
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| Other Names | Norrin, EVR2, FEVR, ND |
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| Gene, Accession, CAS # | NP 000257 |
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| Catalog # | ATGP2290 |
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| Order / More Info | NDP, 25-133aa, Human, His tag, E.coli (Denatured) from ATGen |
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| Product Specific References | n/a |
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