| 产品详情 |
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| Product Name | Macitentan |
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| Description | A dual ETA/ETB receptor antagonist (IC50s = 0.5 and 391 nM in a radioligand binding assay using recombinant ETA and ETB, respectively); inhibits ET-1-induced intracellular Ca2+ increase in HPASMCs (IC50 = 0.9 nM) and contractions of isolated rat aortic rings (pA2 = 7.6 for ETA) and sarafotoxin S6c-induced contractions of isolated rat tracheal rings (pA2 = 5.9 for ETB); decreases mean arterial blood pressure in hypertensive DOCA-salt rats (ED50 = 1 mg/kg); prevents development of pulmonary hypertension and right ventricle hypertrophy in a rat model of hypertension; decreases the number of vascular and tubule-interstitial lesions and amount of glomerular damage in a rat model of diabetes |
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| Size | 25 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | ACT-064992 |
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| Gene, Accession, CAS # | CAS: 441798-33-0 |
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| Catalog # | 23304-25 |
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| Price | |
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| Order / More Info | Macitentan from CAYMAN CHEMICAL COMPANY |
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| Product Specific References | n/a |
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| 产品资料 |
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