| 产品详情 |
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| Product Name | O6-Benzylguanine |
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| Description | Purity >98%. O6 -Alkylguanine-DNA alkyltransferase (AGT, also known as methylguanine DNA methyltransferase, or MGMT) is a DNA repair protein that directly removes alkyl groups located on the O6 -position of guanine from DNA, restoring DNA integrity in a single step. In the process, AGT is alkylated and irreversibly inactivated. O6 -Benzylguanine is a guanine analog with antineoplastic activity. It serves as a pseudosubstrate for AGT, transferring a benzyl moiety to the active site cysteine of the enzyme. This leads to irreversible inactivation, with 40% reduction in alkyltransferase activity of recombinant human AGT achieved at 0.06 µM. O6 -Benzylguanine is effective in vivo as well as in vitro . Inactivation of AGT increases the chemotherapeutic effectiveness of chloroethylating and methylating agents. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 6-(phenylmethoxy)-9H-purin-2-amine, NSC 637037 |
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| Gene, Accession, CAS # | CAS: 19916-73-5 |
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| Catalog # | LS-H9128 |
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| Order / More Info | O6-Benzylguanine from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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