产品名称 O6-Benzylguanine from LIFESPAN BIOSCIENCES INC.
产品货号 LS-H9128
产品价格 现货询价,电话:010-67529703
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产品品牌 LIFESPAN BIOSCIENCES INC.
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Product NameO6-Benzylguanine
DescriptionPurity >98%. O6 -Alkylguanine-DNA alkyltransferase (AGT, also known as methylguanine DNA methyltransferase, or MGMT) is a DNA repair protein that directly removes alkyl groups located on the O6 -position of guanine from DNA, restoring DNA integrity in a single step. In the process, AGT is alkylated and irreversibly inactivated. O6 -Benzylguanine is a guanine analog with antineoplastic activity. It serves as a pseudosubstrate for AGT, transferring a benzyl moiety to the active site cysteine of the enzyme. This leads to irreversible inactivation, with 40% reduction in alkyltransferase activity of recombinant human AGT achieved at 0.06 µM. O6 -Benzylguanine is effective in vivo as well as in vitro . Inactivation of AGT increases the chemotherapeutic effectiveness of chloroethylating and methylating agents.
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Other Names6-(phenylmethoxy)-9H-purin-2-amine, NSC 637037
Gene, Accession, CAS #CAS: 19916-73-5
Catalog #LS-H9128
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Order / More InfoO6-Benzylguanine from LIFESPAN BIOSCIENCES INC.
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