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| Product Name | ADAM Metallopeptidase Domain 10 (ADAM10) (AA 214-672) protein (His tag) |
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| Description | ADAM10 is part of the ADAM family which are cell surface proteins with a distinctive structure possessing both potential adhesion and protease domains. ADAM10 cleaves many proteins including TNF-alpha and E-cadherin. ADAM10 cleaves the membrane-bound precursor of tnf-alpha at 76- ala-|-val-77 to its mature soluble form. ADAM10 is in charge for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-a2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein ADAM10 is involved in the normal cleavage of the cellular prion protein. ADAM10 is involved in the cleavage of the adhesion molecule l1 at the cell surface and in the release of membrane vesicles, suggesting a vesicle-based protease activity. ADAM10 controls the proteolytic processing of notch and mediates lateral inhibition during neurogenesis Synonyms: Kuz, AD10, MADM, CD156c, HsT18717, ADAM metallopeptidase domain 10, A disintegrin and metalloproteinase domain 10, Mammalian disintegrin-metalloprotease, Kuzbanian protein homolog, CDw156, ADAM 10, ADAM10 |
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| Size | 2 µg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | adam10|wu:fc03d12|ADAM10|LOC100219653|Adam10|1700031C13Rik|MADM|kuz|kuzbanian|AD10|CD156c|HsT18717|ad10|cd156c|madm|xadam10|ADAM-10|ADAM 10 |
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| Gene, Accession, CAS # | Gene ID: 102 |
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| Catalog # | ABIN807047 |
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| Order / More Info | ADAM Metallopeptidase Domain 10 (ADAM10) (AA 214-672) protein (His tag) from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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