| 产品详情 |
| Edit |   |
|---|
| Antigenic Specificity | DDR1 |
|---|
| Clone | polyclonal |
|---|
| Host Species | Rabbit |
|---|
| Reactive Species | human |
|---|
| Isotype | n/a |
|---|
| Format | purified |
|---|
| Size | 80 µl, 400 µl |
|---|
| Concentration | n/a |
|---|
| Applications | WB, IHC, FCM. RUO |
|---|
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
|---|
| Description | Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation and metabolism. MCK10 is a RTK that is widely expressed in normal and transformed epithelial cells and is activated by various types of collagen. This protein belongs to a subfamily of tyrosine kinase receptors with a homology region to the Dictyostelium discoideum protein discoidin I in their extracellular domain. Its autophosphorylation is achieved by all collagens so far tested (type I to type VI). In situ studies and Northern-blot analysis showed that expression of this encoded protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, this protein is significantly over-expressed in several human tumors from breast, ovarian, esophageal, and pediatric brain. The gene is located on chromosome 6p21.3 in proximity to several HLA class I genes. This DDR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 17-47 amino acids from the N-terminal region of human DDR1. |
|---|
| Immunogen | Human DDR1. |
|---|
| Other Names | CAK; CD167; CD167 antigen-like family member A; Cell adhesion kinase; DDR; DDR1; discoidin domain receptor family; member 1; discoidin domain receptor tyrosine kinase 1; Discoidin receptor tyrosine kinase; EDDR1; Epithelial discoidin domain receptor 1; Epithelial discoidin domain-containing receptor 1; HGK2; mammarian carcinoma kinase 10; Mammary carcinoma kinase 10; MCK-10; MCK10; NEP; neuroepithelial tyrosine kinase; neurotrophic tyrosine kinase; receptor; type 4; NTRK4; Protein-tyrosine kinase 3A; Protein-tyrosine kinase RTK-6; PTK3; PTK3A; PTK3A protein tyrosine kinase 3A; RTK6; TRK E; TRKE; Tyrosine kinase DDR; Tyrosine-protein kinase CAK; CD167a antigen; Epithelial discoidin domain receptor 1 precursor; Protein-tyrosine kinase RTK 6; Tyrosine- protein kinase CAK; CD167a |
|---|
| Gene, Accession # | Accession: NP_001189450.1, NP_001189451.1, NP_001189452.1, NP_001945.3, NP_054699.2, NP_054700.2, SwissProt: Q08345 |
|---|
| Catalog # | abx033583 |
|---|
| Price | |
|---|
| Order / More Info | DDR1 Antibody from ABBEXA |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|