| 产品详情 |
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| Product Name | Geldanamycin |
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| Description | MW: 560.6. Geldanamycin is a small molecule produced by fermentation. Glendanamycin (GA), a benzoquinone ansamycin antibiotic, interferes with the action of Hsp90 leading to degradation of Hsp90 client proteins. GA itself however has undesirable properties such as poor aqueous solubility and liver toxicity; therefore, numerous analogs have been synthesized, such as 17-AAG(1). 17-AAG is an HSP-90 inhibitor that displays a 100-fold higher affinity for HSP-90 derived from tumor cells compared to HSP-90 from normal cells(2). 17-AAG inhibits Akt activation and expression in tumors and synergizes with a number of antitumor agents such as taxol(3), cisplatin(4) and UCN-01 (400 nM 17-AAG, U937 cells)(5). |
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| Size | 1 mg, 5 mg |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl carbamate |
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| Gene, Accession, CAS # | CAS: 30562-34-6 |
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| Catalog # | abx076533 |
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| Price | |
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| Order / More Info | Geldanamycin from ABBEXA |
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| Product Specific References | n/a |
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