| 产品详情 |
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| Product Name | OLT1177 |
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| Description | An NLRP3 inflammasome inhibitor; inhibits the release of IL-1β and decreases caspase-1 levels in LPS-stimulated J774A.1 murine macrophages, HMDMs, and primary human blood neutrophils; selective for NLRP3 over NLRP4 and AIM2 inflammasomes at concentrations up to 100 µM; inhibits ASC oligomerization and NLRP3 association with caspase-1 and ASC in LPS- and nigericin-stimulated J774A.1 cells; reduces MPO, CXCL1, and IL-6 levels in peritoneal fluid as well as IL-1β levels in liver, lung, spleen, and skeletal muscle in a mouse model of LPS-induced systemic inflammation; increases markers of oxidative metabolism in muscle in mouse model of LPS-induced systemic inflammation; reduces IL-1β release in blood monocytes isolated from patients with CAPS |
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| Size | 50 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | OLT-1177 (Methylsulfonyl)propionitrile Dapansutrile IL-1β NLRP-3-4 AIM-2 CXCL IL6 TNFα |
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| Gene, Accession, CAS # | CAS: 54863-37-5 |
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| Catalog # | 24671-50 |
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| Price | |
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| Order / More Info | OLT1177 from CAYMAN CHEMICAL COMPANY |
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| Product Specific References | n/a |
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| 产品资料 |
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