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| Antigenic Specificity | RIP1 |
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| Clone | OTI2D6 |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG1 |
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| Format | purified |
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| Size | 100 µl |
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| Concentration | n/a |
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| Applications | Immunohistochemistry (Paraffin): 1:150, Western Blot: 1:2000 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | RIP1 Monoclonal Antibody (OTI2D6). Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Phosphorylates DAB2IP at 'Ser-728' in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade. Ubiquitination by TRAF2 via 'Lys-63'-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events including the activation of genes e |
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| Immunogen | n/a |
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| Other Names | OTTHUMP00000015955; RIP-1; cell death protein RIP; receptor interacting protein; receptor-interacting protein 1; receptor-interacting serine/threonine-protein kinase 1; serine/threonine-protein kinase RIP |
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| Gene, Accession # | Entrez: 8737; Uniprot: Q13546 |
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| Catalog # | MA5-26426 |
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| Price | |
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| Order / More Info | RIP1 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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