| 产品详情 |
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| Product Name | ONO-4059 analog |
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| Description | Purity >98%. ONO-4059 analog is the [(3S)-1-(1-oxo-2-propen-1-yl)-3-piperidinyl] analog of the recently published structure of ONO-4059. ONO-4059 is an orally bioavailable inhibitor of Bruton's tyrosine kinase (BTK; IC50 = 2.2 nM), a non-receptor tyrosine kinase involved in signal transduction pathways regulating the proliferation, activation, and differentiation of B cells. ONO-4059 reversibly blocks B cell receptor signaling and B cell proliferation and activation. ONO-4059 suppresses the generation of inflammatory chemokines and cytokines in a mouse model of collagen-induced arthritis, resulting in regression of cartilage erosion, bone damage, and pannus formation. ONO-4059 is in clinical trials concerning certain leukemias and lymphomas, including chronic lymphocytic leukemia. The actions of ONO-4059 analog have not been studied. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 6-amino-7,9-dihydro-9-[(3S)-1-(1-oxo-2-propen-1-yl)-3-piperidinyl]-7-(4-phenoxyphenyl)-8H-purin-8-one, GS-4059 analog |
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| Gene, Accession, CAS # | CAS: 1351635-67-0 |
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| Catalog # | LS-H9192 |
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| Order / More Info | ONO-4059 analog from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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