| 产品详情 |
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| Product Name | GNF-2 |
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| Description | Purity >98%. Bcr-Abl, a fusion protein with deregulated tyrosine kinase activity, is highly expressed in chronic myelogenous leukemia. GNF-2 is a Bcr-Abl inhibitor that binds to the myristoyl binding pocket, an allosteric site distant from the active site, stabilizing the inactive form of the kinase. Thus, it can selectively inhibit Bcr-Abl phosphorylation (IC50 = 267 nM) without affecting native c-Abl or a panel of 63 additional kinases. It demonstrates exclusive antiproliferative activity toward Bcr-Abl-transformed cells (IC50 = 138 nM), inducing apoptosis in these cells without cytotoxic consequences in nontransformed cells. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 3-[6-[[4-(trifluoromethoxy)phenyl]amino]-4-pyrimidinyl]-benzamide, Bcr-Abl inhibitor |
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| Gene, Accession, CAS # | CAS: 778270-11-4 |
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| Catalog # | LS-H7971 |
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| Order / More Info | GNF-2 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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