| 产品详情 |
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| Product Name | KD 025 |
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| Description | Purity >98%. Rho-associated protein kinase II (ROCK-II) regulates the formation of actin stress fibers and focal adhesions, smooth muscle contraction, and gene expression. KD 025 is an orally bioavailable inhibitor of ROCK-II that is greater than 200-fold selective over ROCK-I (IC50 s = 105 nM and 24 µM, respectively). Treatment of fibrosis-derived smooth muscle cells with KD 025 (40 µM) for 24 hours reduces the expression of connective tissue growth factor and remodels actin cytoskeleton. KD 025 decreases cell-spanning F-actin fibers and increases motility of microvascular endoethelial cells. In mice, KD 025 given by oral gavage dose-dependently reduces infarct volume after transient middle cerebral artery occlusion without causing significant hypotension. In humans, oral KD 025 diminishes STAT3 phosphorylation and pro-inflammatory cytokine production in CD4+ T cells while up-regulating phosphorylation of STAT5 in regulatory T cells, altering the immune response. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 2-[3-[4-(1H-indazol-5-ylamino)-2-quinazolinyl]phenoxy]-N-(1-methylethyl)-acetamide, SLx-2119 |
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| Gene, Accession, CAS # | CAS: 911417-87-3 |
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| Catalog # | LS-H8333 |
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| Order / More Info | KD 025 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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