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| Product Name | Hepatitis A Virus Cellular Receptor 2 (HAVCR2) (C-Term) protein |
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| Description | Recombinant Human T-Cell Membrane Protein 3/TIM-3 produced by transfected human cells is a secreted protein with sequence (Ser22-Arg200) of Human TIM3 fused with a FC-6His tag at the C-terminus. Hepatitis A virus cellular receptor 2 (HAVCR2) is a single-pass type I membrane protein and it contains 1 Ig-like V-type (immunoglobulin-like) domain. The protein belongs to the immunoglobulin superfamily, and TIM family of proteins. The protein regulates macrophage activation. It inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. It may be also involved in T-cell homing and it is receptor for LGALS9. CD4 (MIM 186940)-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells and their associated cytokines are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. The 2 types of cells also cross-regulate the functions of the other. TIM3 is a Th1-specific cell surface protein that regulates macrophage activation and enhances the severity of experimental autoimmune encephalomyelitis in mice. |
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| Size | 1 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | HAVCR2|MGC140131|HAVcr-2|KIM-3|TIM3|TIMD-3|TIMD3|Tim-3|TIM-3|Tim3|Timd3|tim3 |
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| Gene, Accession, CAS # | Gene ID: 84868 |
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| Catalog # | ABIN1691760 |
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| Order / More Info | Hepatitis A Virus Cellular Receptor 2 (HAVCR2) (C-Term) protein from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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