| 产品详情 |
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| Antigenic Specificity | COLLAGEN Type I |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, bovine |
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| Isotype | n/a |
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| Format | immunoaffinity purified |
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| Size | 500 µg |
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| Concentration | 1.0 mg/ml |
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| Applications | ELISA, FLISA, Immunohistochemistry, Immunoprecipitation, Western Blot. Anti-Collagen antibodies have been used for indirect trapping ELISA for quantitation of antigen in serum using a standard curve, immunoprecipitation, native (non-denaturing, non-dissociating) PAGE, immunohistochemistry, and western blotting for highly sensitive qualitative analysis. |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Anti-Collagen Type I Antibody has been prepared by immunoaffinity chromatography using immobilized antigens followed by extensive cross-adsorption against other collagens, human serum proteins and non-collagen extracellular matrix proteins to remove any unwanted specificities. Typically negligible cross reactivity against other types of collagens was detected by ELISA against purified standards. Some class-specific anti-collagens may be specific for three-dimensional epitopes which may result in diminished reactivity with denatured collagen or formalin-fixed, paraffin embedded tissues. This antibody reacts with human, bovine, and most mammalian Type I collagens with negligible cross-reactivity with Type II, III, IV, V or VI collagens. Non-specific cross-reaction of anti-collagen antibodies with other human serum proteins or non-collagen extracellular matrix proteins is negligible. |
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| Immunogen | Collagen Type I from human and bovine placenta |
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| Other Names | rabbit anti-collagen type I antibody, Collagen Of Skin Tendon And Bone, Collagen Type 1 antibody, Collagen type I alpha 1 antibody, Collagen alpha-1 (I) chain, Alpha-1 type I collagen, type 1 procollagen alpha 1, Collagen type I alpha 2 antibody |
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| Gene, Accession # | COL1A1/A2, Gene ID: 1277, NCBI: P02452.5, UniProt: P02452 |
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| Catalog # | 600-401-103-0.5 |
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| Price | |
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| Order / More Info | COLLAGEN Type I Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
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| Product Specific References | Stefanovic, B, Schnabl, B, Brenner, DA (2002) Inhibition of collagen alpha 1(I) expression by the 5' stem-loop as a molecular decoy. J.Biol. Chem. 277(20):18229-18237.Hashimoto, N et al. (2004) Bone marrow-derived progenitor cells in pulmonary fibrosis. J. Clin. Invest. 113:243-252.Hazra, S et al. (2004) Peroxisome Proliferator-activated Receptor gamma Induces a Phenotypic Switch from Activated to Quiescent Hepatic Stellate Cells. J. Biol. Chem. 279(12):11392-11401.She, H, Xiong, S, Hazra, S, Tsukamoto, H (2005) Adipogenic transcriptional regulation of hepatic stellate cells. J. Biol. Chem. 280(6):4959-4967.Mak KM, Kwong AJ, Chu E, Hoo NM. (2011) Hepatic Steatosis, Fibrosis, and Cancer in Elderly Cadavers. Cancer Biology. 5 DEC 2011. DOI: 10.1002/ar.21525.Yujie Zhang, Branko Stefanovic. (2016) Akt mediated phosphorylation of LARP6; critical step in biosynthesis of type I collagen. Scientific Reports volume 6, Article number: 22597 (2016)doi:10.1038/srep22597. |
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