| 产品详情 |
| Edit |   |
|---|
| Antigenic Specificity | NOTCH 1, N-terminus |
|---|
| Clone | polyclonal |
|---|
| Host Species | Rabbit |
|---|
| Reactive Species | human, mouse, rat |
|---|
| Isotype | n/a |
|---|
| Format | serum |
|---|
| Size | 200 µL |
|---|
| Concentration | 78 mg/mL |
|---|
| Applications | ELISA, Immunohistochemistry, Western Blot. Anti-Notch 1 is reactive with Notch 1 by western blotting, Immunohistochemistry (IHC) and ELISA. An 80 kDa band corresponding to Notch 1 was observed at a 1:500 dilution. Specific conditions for reactivity should be optimized by the end user. |
|---|
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
|---|
| Description | This antiserum is directed against human NOTCH 1. Based on the immunogen sequence, we expect this antibody to react as well with mouse and rat NOTCH 1 (100% sequence homology). This antibody reacts with mouse Notch constructs present in lysates of HEK 293 cells. Only the cleaved intracellular (activated) form (NICD) is detected. No reactivity is detected against mouse N2, N3 or N4. The immunogen epitope is only exposed after gamma secretase cleavage and is not accessible in the uncleaved form. |
|---|
| Immunogen | This whole rabbit serum was prepared by repeated immunizations with a synthetic peptide corresponding to amino acid residues of human Notch 1 located near the N-terminal sequence of the cleaved N intracellular domain (NICD). |
|---|
| Other Names | rabbit anti-notch1 antibody, Neurogenic locus Notch homolog protein 1, hN1, Translocation-associated Notch protein TAN-1 |
|---|
| Gene, Accession # | NOTCH1, Gene ID: 4851, NCBI: CAG33502.1, UniProt: P46531 |
|---|
| Catalog # | 100-401-407 |
|---|
| Price | |
|---|
| Order / More Info | NOTCH 1, N-terminus Antibody from ROCKLAND IMMUNOCHEMICALS INC. |
|---|
| Product Specific References | Gupta S, Li S, Abedin Md J, Wang L, Schneider E, Najafian B, Rosenberg M. Effect of Notch activation on the regenerative response to acute renal failure. Am J Physiol Renal Physiol 298: F209-F215, 2010. Published online before print October 14, 2009, doi: 10.?1152/?ajprenal.?00451.?2009Solomon A, Mian Y, Ortega-Cava C, et al. Upregulation of the let-7 microRNA with precocious development in lin-12/Notch hypermorphic Caenorhabditis elegans mutants. Dev. Biol. 2008 Apr 15;316(2):191-199. Harrison H, Simoes BM, Rogerson L, Howell SJ, Landberg G, and Clarke RB. (2013) Oestrogen increases the activity of oestrogen receptor negative breast cancer stem cells through paracrine EGFR and Notch signalling. Breast Cancer Research 2013, 15:R21 doi:10.1186/bcr3396.Stylianou S, Clarke RB, Brennan K. Aberrant activation of notch signaling in human breast cancer. Cancer Res. 2006 Feb 1;66(3):1517-1525.E Poli, C Zalfa, F D'Avanzo, R Tomanin, L Carlessi, M Bossi, L Rota Nodari, E Binda, P Marmiroli, M Scarpa, D Delia, A L Vescovi, L De Filippis. (2013) Murine neural stem cells model Hunter disease in vitro: glial cell-mediated neurodegeneration as a possible mechanism involved. Cell Death & Disease vol4, page e906. |
|---|
| 产品资料 |
|
|