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| Product Name | GSK4716 |
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| Description | Purity >98%. The estrogen-related receptors (ERRs) are orphan nuclear receptors with homology to the estrogen receptor family and are expressed in tissues with high metabolic demand. Binding of peroxisome proliferator-activated receptor Gamma-coactivator 1Alpha (PGC-1Alpha) to this class of receptors is known to potentiate ERR activity. GSK4716 is an ERRBeta/Gamma agonist (IC50 = 2 µM) that can activate the receptor with similar potency as the protein ligand, PGC-1Alpha. It is more than 50-fold selective for binding to ERRBeta/Gamma compared with the estrogen receptors. This compound has been used to demonstrate the contribution of ERR receptor activity to the regulation of mitochondrial activity in skeletal muscle during exercise. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 4-hydroxy-2-[[4-(1-methylethyl)phenyl]methylene]hydrazide benzoic acid |
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| Gene, Accession, CAS # | CAS: 101574-65-6 |
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| Catalog # | LS-H8017 |
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| Order / More Info | GSK4716 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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