产品详情 |
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Antigenic Specificity | PION (aa 536-565) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | unconjugated |
Size | n/a |
Concentration | n/a |
Applications | WB |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Rabbit Anti-Human PION polyclonal antibody for WB. Accumulation of neurotoxic amyloid-beta is a major hallmark of Alzheimer disease (AD; MIM 104300). Formation of;amyloid-beta is catalyzed by gamma-secretase (see PSEN1; MIM 104311), a protease with numerous substrates. PION, or;GSAP, selectively increases amyloid-beta production through a mechanism involving its interaction with both;gamma-secretase and its substrate, the amyloid-beta precursor protein (APP; MIM 104760) C-terminal fragment (APP-CTF);(He et al., 2010 (PubMed 20811458)). |
Immunogen | Synthetic peptide |
Other Names | n/a |
Gene, Accession # | Gene ID: 54103, UniProt: A4D1B5 |
Catalog # | CABT-BL2902 |
Price | |
Order / More Info | PION (aa 536-565) Antibody from CREATIVE DIAGNOSTICS |
Product Specific References | n/a |
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