| 产品详情 |
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| Antigenic Specificity | GAD65 |
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| Clone | 144 |
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| Host Species | Mouse |
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| Reactive Species | human, mouse, rat |
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| Isotype | IgG1 |
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| Format | purified |
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| Size | 100 µL |
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| Concentration | n/a |
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| Applications | Flow Cytometry: Assay-dependent, Immunoprecipitation: Assay-dependent, Radioimmune Assays: Assay-dependent, Western Blot: 1 µg/mL |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | GAD65 Monoclonal Antibody (144). Antibodies to glutamic acid decarboxylase-65 (GAD65) are present in autoimmune disorders such as insulin-dependent (type1) diabetes mellitus (IDDM), stiff man syndrome and polyendocrine autoimmune disease. Auto-antibodies to GAD65 are present in 60-70% of individuals with newly diagnosed IDDM and thus are important markers for disease activity. These auto-antibodies usually recognize conformation-dependent regions on GAD65 and rarely bind to the second isoform, GAD67. Auto-antibodies to GAD67 are found in only 15% of recent-onset IDDM patients and most of this binding can be blocked with GAD65, suggesting shared epitopes between the two isoforms of GAD. |
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| Immunogen | n/a |
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| Other Names | Glutamate decarboxylase 2; 65 kDa glutamic acid decarboxylase; Glutamate decarboxylase 65 kDa isoform; 65 kDa glutamic acid decarboxylase |
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| Gene, Accession # | Entrez: 14417, 24380, 2572; Uniprot: P48320, Q05329, Q05683 |
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| Catalog # | MA5-18053 |
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| Price | |
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| Order / More Info | GAD65 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | PubMed: 25800737 |
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