| 产品详情 |
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| Product Name | (-)-Neplanocin A |
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| Description | Purity >98%. S-Adenosylhomocysteine (SAH) hydrolase catalyzes the reversible hydrolysis of SAH to adenosine and homocysteine. The inhibition of SAH hydrolase causes the intracellular accumulation of SAH, elevating the ratio of SAH to S-adenosylmethionine (SAM) and inhibiting SAM-dependent methyltransferase. (-)-Neplanocin A potently and irreversibly inactivates SAH hydrolase (Ki = 8.39 nM). It has antitumor activity against mouse leukemia L1210 cells and broad-spectrum antiviral activity. Neplanocin A is more potent against vesicular stomatitis than the reversible SAH hydrolase inhibitor 3-deazaneplanocin (ID50 = 0.07 and 0.3 µg/ml, respectively). |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 5R-(6-amino-9H-purin-9-yl)-3-(hydroxymethyl)-3-cyclopentene-1S,2R-diol |
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| Gene, Accession, CAS # | CAS: 72877-50-0 |
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| Catalog # | LS-H5456 |
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| Price | |
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| Order / More Info | (-)-Neplanocin A from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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