| 产品详情 |
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| Antigenic Specificity | Rabbit Fibrinogen |
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| Clone | polyclonal |
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| Host Species | Sheep |
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| Reactive Species | rabbit |
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| Isotype | n/a |
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| Format | peroxidase (HRP) conjugate |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | IEP, ELISA |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Sheep Anti-Rabbit Fibrinogen polyclonal antibody for IEP, ELISA. Fibrinogen is an abundant plasma protein (5-10 µM) produced in the liver. The intact protein has a molecular weight of 340 kDa and is composed of 3 pairs of disulphide-bound polypeptide chains named Aα, Bβ and β. Fibrinogen is a triglobular protein consisting of a central E domain and terminal D domains. Proteolysis by thrombin results in release of Fibrinopeptide A (FPA, Aα1-16) followed by Fibrinopeptide B (FPB, Bβ1-14) and the fibrin monomers that result polymerize in a half-overlap fashion to form insoluble fibrin fibrils. The chains of fibrin are referred to as α, β and β, due to the removal of FPA and FPB. The polymerised fibrin is subsequently stabilized by the transglutaminase activated Factor XIII that forms amide linkages between β chains and, to a lesser extent, α chains of the fibrin molecules. Proteolysis of fibrinogen by plasmin initially liberates Cterminal residues from the Aα chain to produce fragment X (intact DE-D, which is still clottable). Fragment X is further degraded to nonclottable fragments Y (D-E) and D. Fragment Y can be digested into its constituent D and E fragments. Digestion of non-crosslinked fibrin with plasmin is very similar to the digestion of fibrinogen, which results in production of fragments D and E. Degradation of crosslinked fibrin by plasmin results in fragment DD (D-Dimer consisting of the D domains of 2 fibrin molecules crosslinked via the β chains), fragment E (central E domain) as well as DDE in which fragment E is non-covalently associated with DD. For human crosslinked fibrin, the relative weights of the cleavage fragments produced are: 184 kDa for fragment DD, 92 kDa for D, 50 kDa for E, 1.54 kDa for FP A and 1.57 kDa for FPB. |
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| Immunogen | Rabbit fibrinogen purified from plasma. |
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| Other Names | n/a |
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| Gene, Accession # | Gene ID: 100353616, UniProt: G1T0X2 |
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| Catalog # | CABT-L395 |
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| Price | |
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| Order / More Info | Rabbit Fibrinogen Antibody from CREATIVE DIAGNOSTICS |
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| Product Specific References | n/a |
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