| 产品详情 |
| Edit |   |
|---|
| Antigenic Specificity | Human Vitronectin |
|---|
| Clone | polyclonal |
|---|
| Host Species | Sheep |
|---|
| Reactive Species | human |
|---|
| Isotype | n/a |
|---|
| Format | unconjugated |
|---|
| Size | n/a |
|---|
| Concentration | n/a |
|---|
| Applications | IEP, ELISA |
|---|
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
|---|
| Description | Sheep Anti-Human Vitronectin polyclonal antibody for IEP, ELISA. Vitronectin (Vn), previously known as serum-spreading factor or S-protein, is a plasma and serum glycoprotein with a normal concentration ranging from 200-400 g/ml. It exists in both a 75 kDa single-chain form and a 65 + 10 kDa two-chain form. Vitronectin can exist in a least two different conformational forms. The majority of Vn found in the circulation is present in the native (closed) form. In this form, most of the binding sites for other ligands are cryptic. The second form of Vn, the denatured (open, multimeric) form, is a result of a conformational change in the native protein induced by denaturants such as urea, adsorption onto surfaces, low pH or reduction and alkylation. This conformational change leads to exposure of the heparin binding site, formation of disulfide-bonded multimers and rupture of the disulfide bond that links the 10 kDa light chain to the 65 kDa heavy chain of the two chain form. The liver is the primary site of Vn synthesis, however, Vn is also found in platelets, megakaryocytes, monocytes and macrophages. Vn plays an important role in a number of physiological and pathophysiological processes. It promotes the adhesion and spreading of a wide variety of cell types and is a subcomponent of the soluble SC5b-9 complex of complement where it protects bystander cells from cytolysis. Vn also plays an important role in fibrinolysis by stabilizing PAI-1 in its active conformation which otherwise rapidly converts to a latent form. |
|---|
| Immunogen | Human Vitronectin purified from plasma. |
|---|
| Other Names | n/a |
|---|
| Gene, Accession # | Gene ID: 7448, UniProt: P04004 |
|---|
| Catalog # | CABT-L512 |
|---|
| Price | |
|---|
| Order / More Info | Human Vitronectin Antibody from CREATIVE DIAGNOSTICS |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|