| 产品详情 |
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| Antigenic Specificity | Human IL4 |
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| Clone | polyclonal |
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| Host Species | Goat |
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| Reactive Species | human |
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| Isotype | n/a |
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| Format | biotin conjugate |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | ELISA(Det), ICC/IF, WB |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Goat Anti-Human IL4 polyclonal antibody for ELISA(Det), ICC/IF, WB. Interleukin-4 (IL-4), also known as B cell-stimulatory factor-1, is a monomeric, approximately 13-18 kDa Th2 cytokine that shows pleiotropic effects during immune responses. It is a glycosylated polypeptide that contains three intrachain disulfide bridges and adopts a bundled four alpha-helix structure. Human IL-4 is synthesized with a 24 aa signal sequence. Alternate splicing generates an isoform with a 16 aa internal deletion. Mature human IL-4 shares 55%, 39%, and 43% aa sequence identity with bovine, mouse, and rat IL-4, respectively. Human, mouse, and rat IL-4 are species-specific in their activities. IL-4 exerts its effects through two receptor complexes. The type I receptor, which is expressed on hematopoietic cells, is a heterodimer of the ligand binding IL-4 R alpha and the commongamma chain (a shared subunit of the receptors for IL-2,-7,-9,-15, and-21). The type II receptor on nonhematopoietic cells consists of IL-4 R alpha and IL-13 R alpha 1. The type II receptor also transduces IL-13 mediated signals. IL-4 is primarily expressed by Th2-biased CD4+ T cells, mast cells, basophils, and eosinophils. It promotes cell proliferation, survival, and immunoglobulin class switch to IgG4 and IgE in human B cells, acquisition of the Th2 phenotype by naive CD4+ T cells, priming and chemotaxis of mast cells, eosinophils, and basophils, and the proliferation and activation of epithelial cells. IL-4 plays a dominant role in the development of allergic inflammation and asthma. |
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| Immunogen | Recombinant Protein |
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| Other Names | n/a |
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| Gene, Accession # | Gene ID: 3565, UniProt: P24394 |
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| Catalog # | CABT-L214 |
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| Price | |
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| Order / More Info | Human IL4 Antibody from CREATIVE DIAGNOSTICS |
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| Product Specific References | n/a |
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