| 产品详情 |
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| Antigenic Specificity | Human IkB alpha (phospho Ser32) |
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| Clone | C.253.8 |
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| Host Species | Rabbit |
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| Reactive Species | bovine, dog, chicken, guinea pig, human, mouse, nonhuman primate, porcine, rat |
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| Isotype | IgG |
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| Format | unconjugated |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | IP, WB |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Rabbit Anti-Human IkB alpha (phospho Ser32) monoclonal antibody for IP, WB. NFKB1 or NFKB2 is bound to REL, RELA, or RELB to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA or NFKBIB, MIM 604495), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664, or IKBKB, MIM 603258) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine). |
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| Immunogen | Synthetic phosphopeptide corresponding to residues surrounding pSer32 of human IkB alpha. |
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| Other Names | n/a |
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| Gene, Accession # | Gene ID: 1147, UniProt: O15111 |
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| Catalog # | CABT-L1242 |
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| Price | |
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| Order / More Info | Human IkB alpha (phospho Ser32) Antibody from CREATIVE DIAGNOSTICS |
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| Product Specific References | n/a |
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