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| Product Name | serpin Peptidase Inhibitor, Clade F (Alpha-2 Antiplasmin, Pigment Epithelium Derived Factor), Member 1 (SERPINF1) protein |
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| Description | PEDF is a noninhibitory serpin with neurotrophic, anti-angiogenic, and anti-tumorigenic properties. It is a 50 kDa glycoprotein produced and secreted in many tissues throughout the body. A major component of the anti-angiogenic action of PEDF is the induction of apoptosis in proliferating endothelial cells. In addition, PEDF is able to inhibit the activity of angiogenic factors such as VEGF and FGF-2. The neuroprotective effects of PEDF are achieved through suppression of neuronal apoptosis induced by peroxide, glutamate, or other neurotoxins. The recent identification of a lipase-linked cell membrane receptor for PEDF (PEDF-R) that binds to PEDF with high affinity should facilitate further elucidation of the underlying mechanisms of this pluripotent serpin. To date, PEDF-R is the only signaling receptor known to be used by a serpin family member. The unique range of PEDF activities implicate it as a potential therapeutic agent for the treatment of vasculature related neurodegenerative diseases such as age-related macular degeneration (AMD) and proliferative diabetic retinopathy (PDR). PEDF also has the potential to be useful in the treatment of various angiogenesis-related diseases including a number of cancers. |
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| Size | 20 µg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | MGC82984|SERPINF1|PEDF|1110001C14Rik|ATGL|PEDF-R|TTS-2.2|TTS2|iPLA2zeta|AI195227|EPC-1|Pedf|Pedfl|Sdf3|OI12|OI6|Dmrs91 |
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| Gene, Accession, CAS # | Gene ID: 5176 |
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| Catalog # | ABIN1540557 |
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| Order / More Info | serpin Peptidase Inhibitor, Clade F (Alpha-2 Antiplasmin, Pigment Epithelium Derived Factor), Member 1 (SERPINF1) protein from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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