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| Antigenic Specificity | Suppressor of Cytokine Signaling 1 (SOCS1) (aa 2-78) |
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| Clone | 4H1 |
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| Host Species | Mouse |
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| Reactive Species | mouse |
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| Isotype | IgG1 |
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| Format | biotin conjugate |
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| Size | 100 µL |
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| Concentration | n/a |
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| Applications | Western Blotting (WB) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | The Suppressor of Cytokine Signaling (SOCS) family of proteins act in a classic negative feedback loop to regulate cytokine signal transduction. SOCS-1, also designated Janus kinase [JAK] binding protein (JAB), or STAT-induced STAT inhibitor (SSI-1), is a 24 kDa protein containing an SH2 domain. SOCS-1 inhibits both IL-6-induced receptor phosphorylation and STAT activation. SOCS-1 is also induced by and inhibits the signaling action of IL-3, IL-4, LIF, prolactin, and erythropoietin. Additionally, SOCS-1 can associate with all 4 JAK family kinases, and is an important regulator of the JAK-STAT signaling pathway. SOCS-1 is found primarily in thymocytes, where it plays a key role in the negative regulation of IFN- γ signaling and T cell differentiation.Synonyms: JAB, JAK-binding protein, SOCS-1, SSI-1, SSI1, STAT-induced STAT inhibitor 1, Suppressor of cytokine signaling 1, TIP-3, TIP3, Tec-interacting protein 3 |
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| Immunogen | n/a |
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| Other Names | socs1|zgc:91868|jab|cis1|ssi1|tip3|cish1|ssi-1|socs-1|SOCS1|LOC100228306|socs1b|CIS1|CISH1|JAB|SOCS-1|SSI-1|SSI1|TIP3|Cish1|Cish7|Socs-1 |
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| Gene, Accession # | Gene ID: 12703 |
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| Catalog # | ABIN2853615 |
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| Price | |
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| Order / More Info | Suppressor of Cytokine Signaling 1 (SOCS1) (aa 2-78) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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