| 产品详情 |
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| Product Name | fluoro-Dapagliflozin |
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| Description | Purity >95%. Dapagliflozin is a selective sodium-glucose cotransporter (SGLT) inhibitor that blocks glucose transport with about 100-fold selectivity for SGLT2 (Ki = 6 nM; EC50 = 1.1 nM) over SGLT1 (Ki = 390 nM). It improves glucose tolerance in normal rats and reduces hyperglycemia in Zucker diabetic fatty rats. fluoro-Dapagliflozin is an analog of dapagliflozin that displays similar selectivity for inhibiting SGLT2 over SGLT1 (Ki s = 5.3 and 330 nM, respectively). fluoro-Dapagliflozin (10 nM) significantly reduces phlorizin-sensitive sugar transport in COS-1 cells expressing human SGLT2. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | (1S)-1,5-anhydro-1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-4-deoxy-4-fluoro-D-glucitol, flouro-DAPA |
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| Gene, Accession, CAS # | CAS: 1181681-43-5 |
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| Catalog # | LS-H7821 |
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| Order / More Info | fluoro-Dapagliflozin from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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