| 产品详情 |
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| Antigenic Specificity | Radioprotective 105 |
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| Clone | RP-14 |
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| Host Species | Rat |
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| Reactive Species | mouse |
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| Isotype | n/a |
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| Format | fluorescein (FITC) conjugate |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | Flow Cytometry (FACS) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Radioprotective 105 (RP105, CD180) is a type 1 transmembrane protein of 105 kDa with extracellular leucine-rich repeats (LLRs) and a short cytoplasmic tail. RP105, assigned as CD180, is similar to Drosophila Toll in the extracellular LLRs. Radioprotective 105 (RP105, CD180) expression is largely + restricted to immune cells including CD19 B cells and macrophages. Histological studies showed that RP105 is expressed mainly on mature B cells in mantle zones. Antibody-mediated (RP/14) cross-linking of RP105 induces resistance against irradiation-induced apoptosis, B-cell proliferation, and up-regulation of a costimulatory molecule B7.2, revealing RP105 as a potent regulator of B-cell activation. RP105 (CD180) has an important role in B-cell activation by LPS. It is important to note that RP105 associates with MD1, which is in this context important for RP105 with respect to B-cell surface expression and LPS recognition and signalling. MD-1 seems to be requisite for efficient expression of RP105. Aliases RP105, Ly78 |
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| Immunogen | n/a |
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| Other Names | n/a |
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| Gene, Accession # | n/a |
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| Catalog # | ABIN2191771 |
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| Price | |
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| Order / More Info | Radioprotective 105 Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | PubMed: 9686597, 11861286 |
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