| 产品详情 |
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| Antigenic Specificity | Amphiregulin (AREG) (aa 8-26) |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, mouse |
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| Isotype | n/a |
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| Format | Protein A purified |
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| Size | 0.5 mg |
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| Concentration | n/a |
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| Applications | Immunoprecipitation (IP) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Amphiregulin (AR) binds to EGF-Receptor (EGFR) with lower affinity than EGF. The mature secreted form AR is an 84-amino acid residue glycosylated polypeptide growth regulator, which is generated by proteolytic processing of a 252-amino acid transmembrane precursor. Seven different polypeptide ligands, which derive from distinct genes, are capable of binding to the extracellular domain of EGFR. These ligands include EGF, TGFalpha, AR, HB-EGF, cripto-1, epiregulin, and betacellulin. All of these growth factors contain a characteristic EGF-like domain which is defined by 6 evenly spaced cysteine residues that generate 3 loops through the formation of disulfide bonds. AR protein has been localized by immunohistochemistry to the epithelium of the colon, stomach, pancreas, breast, and placenta. AR is reportedly overexpressed in human cancers of breast, colon, stomach, and pancreas.Synonyms: AREG, CRDGF, Colorectum cell-derived growth factor, SDGF, Schwannoma-Derived Growth Factor |
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| Immunogen | A synthetic 19-mer peptide, corresponding to aa 8-26 (VKPPQNKTESENTSDKPKR) from the secreted amphiregulin of human origin. |
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| Other Names | AR|Sdgf|CRDGF|SDGF|AREG|AREG/SDGF|AREGB |
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| Gene, Accession # | Gene ID: 727738,11839 |
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| Catalog # | ABIN181313 |
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| Price | |
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| Order / More Info | Amphiregulin (AREG) (aa 8-26) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | PubMed: 1639855, 8360173 |
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