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| Antigenic Specificity | Protocadherin gamma Subfamily C, 3 (PCDHGC3) (aa 720-804), (Cytoplasmic Domain) |
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| Clone | S174B-27 |
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| Host Species | Mouse |
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| Reactive Species | mouse |
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| Isotype | n/a |
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| Format | Protein G purified |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | Immunocytochemistry (ICC),Immunofluorescence (IF),Western Blotting (WB) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. PCDHGC3 is a potential calcium-dependent cell-adhesion protein. It may be involved in the establishment and maintenance of specific neuronal connections in the brain. This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes. Cellular Localization: Cell Membrane |
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| Immunogen | Fusion protein amino acids 720-804 (variable cytoplasmic domain) of mouse Gamma- protocadherin-C3. Human: 97% identity (83/85 amino acids identical). Rat: 97% identity (83/85 amino acids identical). No significant identity with other Gamma-protocadherin proteins. |
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| Other Names | PC43|PCDH-GAMMA-C3|PCDH2|Pcdh2|PCDHGA11|PCDHGC5 |
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| Gene, Accession # | n/a |
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| Catalog # | ABIN1741503 |
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| Price | |
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| Order / More Info | Protocadherin gamma Subfamily C, 3 (PCDHGC3) (aa 720-804), (Cytoplasmic Domain) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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