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| Product Name | KIN-59 |
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| Description | Purity >98%. KIN59 is a purine riboside derivative that allosterically inhibits thymidine phosphorylase (TPase; IC50 s = 44 and 67 µM for purified E. coli and human enzymes, respectively). Through this action, KIN59 blocks the conversion of thymidine to thymine. KIN59 inhibits TPase-induced angiogenesis in a chicken chorioallantoic membrane assay and reduces endothelial cell migration without impacting proliferation. KIN59 also inhibits the binding of fibroblast growth factor 2 (FGF2) to FGF receptor 1, preventing the growth and neovascularization of subcutaneous tumors induced by FGF2-transformed endothelial cells injected in immunodeficient nude mice. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 5'-O-(triphenylmethyl)-inosine, 5'-O-Tritylinosine |
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| Gene, Accession, CAS # | CAS: 4152-77-6 |
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| Catalog # | LS-H8348 |
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| Order / More Info | KIN-59 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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