产品名称 CBFB Antibody from ABBEXA
产品货号 abx004055
产品价格 现货询价,电话:010-67529703
产品规格 50 µl, 100 µl, 200 µl
产品品牌 ABBEXA
产品概述
产品详情
Edit&nbsp
Antigenic SpecificityCBFB
Clonepolyclonal
Host SpeciesRabbit
Reactive Specieshuman, mouse
Isotypen/a
Formataffinity purified
Size50 µl, 100 µl, 200 µl
Concentration> 1 mg/ml
ApplicationsWB, IHC, IF/ICC. RUO
Reviews / RatingsIf you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
DescriptionCBFB Antibody is a Rabbit Polyclonal antibody against CBFB. The protein encoded by this gene is the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family which master-regulates a host of genes specific to hematopoiesis (e.g., RUNX1) and osteogenesis (e.g., RUNX2). The beta subunit is a non-DNA binding regulatory subunit; it allosterically enhances DNA binding by alpha subunit as the complex binds to the core site of various enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers and GM-CSF promoters. Alternative splicing generates two mRNA variants, each encoding a distinct carboxyl terminus. In some cases, a pericentric inversion of chromosome 16 [inv(16)(p13q22)] produces a chimeric transcript consisting of the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain 11. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Two transcript variants encoding different isoforms have been found for this gene.
ImmunogenRecombinant protein of human CBFB.
Other NamesCBFB; CBF beta; PEBP2B; PEA2 beta; PEBP2 beta; Core-binding factor subunit beta; Polyomavirus enhancer-binding protein 2 beta subunit; SL3-3 enhancer factor 1 subunit beta; SL3/AKV core-binding factor beta subunit; core-binding factor, beta subunit; CBF-beta; PEA2-beta; PEBP2-beta; SL3-3 enhancer factor 1 beta subunit; polyomavirus enhancer
Gene, Accession #CBFB, Gene ID: 865, SwissProt: Q13951
Catalog #abx004055
Price
Order / More InfoCBFB Antibody from ABBEXA
Product Specific Referencesn/a
产品资料