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| Product Name | Human CD80 Recombinant (B7-1) |
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| Description | MW: 33,048 Da. Purity >90%, as determined by SDS-PAGE and HPLC. CD80 is a monomeric surface protein found on activated APCs. The extracellular region of CD80 consists of two highly glycosylated Ig- like extracellular domains, which have defined regions for binding its ligands, CD28 or CTLA-4, on T cells.One ligand of CD80, CD28, provides critical costimulatory signals to activated T cells to increase cytokine production, cell proliferation, and cell viability, while the other ligand, CTLA-4, may |
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| Size | 0.05 mg, 0.2 mg, 1 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | [Human CD80 Recombinant (B7-1) ; CD80; B7-1] |
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| Gene, Accession, CAS # | CD80, Gene ID: 941, Accession: NP_005182.1 |
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| Catalog # | MBS553137 |
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| Order / More Info | Human CD80 Recombinant (B7-1) from MYBIOSOURCE INC. |
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| Product Specific References | • tumor cell programmed death ligand 1-mediated t cell suppression is overcome by coexpression of CD80 .J. Immunol., Jun 2011; 186: 6822 - 6829. • toll-like receptor 3 ligands induce CD80 expression in human podocytes via an nf-b-dependent pathway .Nephrol. Dial. Transplant., May 2011; 10.1093/ndt/gfr271. • trans-endocytosis of CD80 and cd86: a molecular basis for the cell-extrinsic function of ctla-4 .Science, Apr 2011; 332: 600 - 603. • critical role of transcription factor |
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