产品名称 Solute Carrier Family 6 (Neurotransmitter Transporter, GABA), Member 1 (SLC6A1) (aa 473-487), (C-Term) Antibody from ANTIBODIES-ONLINE GmbH
产品货号 ABIN1673200
产品价格 现货询价,电话:010-67529703
产品规格 100 µg
产品品牌 ANTIBODIES-ONLINE GmbH
产品概述
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Antigenic SpecificitySolute Carrier Family 6 (Neurotransmitter Transporter, GABA), Member 1 (SLC6A1) (aa 473-487), (C-Term)
Clonepolyclonal
Host SpeciesRabbit
Reactive Speciesmouse, rat
Isotypen/a
Formatimmunogen affinity purified
Size100 µg
Concentrationn/a
ApplicationsWestern Blotting (WB),Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Reviews / RatingsIf you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
DescriptionSLC6A1(Solute Carrier family 6(Neurotransmitter transporter, Gaba), Member 1), also called GABATR or GABATHG, encodes a gamma-aminobutyric acid(GABA) transporter, which removes GABA from the synaptic cleft. The SLC6A1 gene contains 15 exons and is approximately 25 kb by Lam et al. And it is mapped on 3p25.3. Zomot et al.(2007) showed that introduction of a negatively charged amino acid at or near 1 of the 2 putative sodium binding sites of the GABA transporter GAT1 from rat brain(also calledSLC6A1) renders both net flux and exchange of GABA largely chloride independent. By in vitro functional expression studies, the SLC6A1 insertion promoter(2 copies of the sequence) had significantly greater promoter activity than the noninsertion(1 copy of the sequence) promoter, which in turn had greater activity than a promoterless control. Studies of postmortem hippocampus from 69 African American individuals showed that the SLC6A1promoter genotype predicted SLC6A1 RNA expression and that overall SLC6A1 expression decreased with age.
ImmunogenA synthetic peptide corresponding to a sequence at the C-terminus of human GABA Transporter 1(473-487aa WFYGVNRFYDNIQEM), identical to the related rat and mouse sequences.
Other NamesA730043E01|GABATHG|GABATR|GAT-1|Gabt|Gabt1|Gat1|XT-1|Xtrp1|si:ch211-280e18.1|si:dkey-164m14.1|slc6a1|GAT1
Gene, Accession #Gene ID: 232333,79212
Catalog #ABIN1673200
Price
Order / More InfoSolute Carrier Family 6 (Neurotransmitter Transporter, GABA), Member 1 (SLC6A1) (aa 473-487), (C-Term) Antibody from ANTIBODIES-ONLINE GmbH
Product Specific ReferencesPubMed: 8530094, 19966779, 17704762
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