| 产品详情 |
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| Product Name | CHR-6494 |
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| Description | Purity >98%. CHR-6494 is a haspin protein kinase inhibitor (IC50 = 2 nM) selective over 27 other protein kinases, including Aurora B kinase (IC50 > 1 µM). Haspin is a kinase necessary for mitosis that selectively phosphorylates histone 3 at the threonine 3 residue (H3T3ph). CHR-6494 decreases phosphorylation of H3T3 and arrests the cell cycle in the G2 /M phase, which leads to apoptosis. It showed promising results in a xenograft tumor model. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 3-(1H-indazol-5-yl)-N-propyl-imidazo[1,2-b]pyridazin-6-amine |
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| Gene, Accession, CAS # | CAS: 1333377-65-3 |
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| Catalog # | LS-H7126 |
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| Order / More Info | CHR-6494 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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