| 产品详情 |
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| Antigenic Specificity | Calpain 1 (CAPN1) (aa 312-326) |
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| Clone | polyclonal |
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| Host Species | n/a |
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| Reactive Species | human, mouse, rat |
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| Isotype | n/a |
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| Format | unconjugated |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | Western Blotting (WB),Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Calpain-1 catalytic subunit is a protein that in humans is encoded by the CAPN1 gene. Calpain is an intracellular protease that requires calcium for its catalytic activity. Two isozymes, calpain I (mu-calpain) and calpain II (m-calpain), with different calcium requirements, have been identified. Both are heterodimers composed of L (large, catalytic, 80 kD) and S (small, regulatory, 30 kD) subunits. The isozymes share an identical S subunit, with the differences arising from the L subunits, L1 (CAPN1) and L2. By quantitative RT-PCR, Ueyama et al. (1998) found that expression of calpain-1 and calpain-2 mRNA was significantly increased in muscle biopsy samples derived from 5 men with progressive muscular dystrophy (e.g., DMD, 310200) and 2 men and 3 women with amyotrophic lateral sclerosis (ALS, 105400) compared with controls. Using cDNA clones as probes, Ohno et al. (1989, 1990) assign CANPL1 to chromosome 11. |
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| Immunogen | A synthetic peptide corresponding to a sequence at the middle region of human Calpain-1 (312-326 aa), different from the mouse sequence by two amino acids. |
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| Other Names | CAPN1|Capa-1|Capa1|mu-calpin|Capn1|fj67g01|wu:fj67g01 |
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| Gene, Accession # | Gene ID: 12333 |
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| Catalog # | ABIN965738 |
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| Price | |
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| Order / More Info | Calpain 1 (CAPN1) (aa 312-326) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | PubMed: 2852952 |
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