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| Antigenic Specificity | Succinate Dehydrogenase Complex, Subunit B, Iron Sulfur (Ip) (SDHB) (N-Term) |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, rat |
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| Isotype | n/a |
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| Format | immunogen affinity purified |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | Western Blotting (WB),Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | SDHB(Succinate Dehydrogenase Complex, Subunit B, iron sulfur protein), also known as iron-sulfur subunit of complex II(Ip) or SDH2, HOMOLOG OF, is a protein that in humans is encoded by the SDHB gene. SDHB is one of four protein subunits forming succinate dehydrogenase, the other three being SDHA, SDHC and SDHD. The SDHB subunit is connected to the SDHA subunit on the hydrophilic, catalytic end of the SDH complex. The SDHB gene is mapped on 1p36.13. The entire SDHB transcript is encoded by 8 exons within approximately 40 kb by Au et al(1995). Pollard et al.(2005) stated that the nuclear-encoded Krebs cycle enzymes fumarate hydratase and succinate dehydrogenases like SDHB act as tumor suppressors, and germline mutations in these genes predispose individuals to leiomyomas and renal cancer and to paragangliomas, respectively. In affected members of families with paragangliomas-4, mutations were identified in the SDHB gene. |
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| Immunogen | A synthetic peptide corresponding to a sequence at the N-terminus of human SDHB(42-59 FAIYRWDPDKAGDKPHMQ), different from the related rat sequence by one amino acid and mouse sequence by two amino acids. |
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| Other Names | succinate dehydrogenase 2-3|CG3283|Dmel\\CG3283|Ip|SDH|SDH-IP|SDH-Ip|SDHb|sdhB|CWS2|IP|PGL4|SDH1|SDH2|SDHIP|0710008N11Rik|fj46d06|wu:fj46d06 |
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| Gene, Accession # | Gene ID: 6390,298596 |
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| Catalog # | ABIN1673197 |
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| Price | |
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| Order / More Info | Succinate Dehydrogenase Complex, Subunit B, Iron Sulfur (Ip) (SDHB) (N-Term) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | PubMed: 7622059, 16912137, 15987702 |
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